GUOFA LIU LAB
Welcome to the GUOFA LIU LAB, a developmental neuroscience lab at the Department of Molecular, Cellular and Developmental Biology, University of Toledo. We are dedicated to advancing the understanding of the developing nervous system and its associaed neurodegenerative disorders.
Our Research
At GUOFA LIU LAB, our research focuses on investigating the molecular and cellular mechanisms underlying neuronal circuit formation and neurodevelopmental disorders. Our team is committed to unraveling the complexities of central nervous system development and exploring potential therapeutic targets. We aim to make significant contributions to the field of developmental neuroscience, ultimately leading to improved treatments for neurological conditions. Click below to learn more about our ongoing projects and achievements.
The human brain possesses approximately 10^11 neurons and 10^14 synapses forming an extraordinarily complex and highly precise network. The formation of proper neural circuitry relies on appropriate neuronal migration, axon guidance, and synapse formation during neural development and following injury. Defects in axon guidance and neuronal migration are implicated in a variety of brain disorders, such as lissencephaly, double cortex, periventricular heterotopia, epilepsy, autism, schizophrenia, dyslexia, Alzheimer’s disease, Parkinson’s disease, stroke, traumatic brain injury, and spinal cord injury. We are interested in studying the molecular mechanisms underlying neuronal guidance with a goal of providing better therapeutic interventions for neurological disorders.
In our lab, we leverage the power of two model organisms, developing chicken embryos and mice, to unlock the fundamental insights into developmental biology. Both organisms offer unique advantages that help us probe the mysteries of early life and biological processes.
